As concerning the gospel, they are enemies for your sakes: but as touching the election, they are beloved for the fathers’ sakes.  (29)  For the gifts and calling of God are without repentance. 

Romans 11:28-29 

Explanation:

When it comes to the gospel and the great commission, many of the Jews had made themselves the enemies of these gentile believers.  They did not recognize Jesus as Messiah, and had at times even persecuted local assemblies of believers in Christ.  In that sense the Jews as a category of people had made themselves the enemies of the gospel.  Paul makes the distinction though, that this did not mean God was going to abandon Israel.  Israel was and is still going to be the chosen people of God because God had made promises to the patriarchs like Abraham and David.  God will fulfill the covenant He made to Israel through Abraham, David and others.  This does not mean that every Jew will be saved.  It does mean that every Jew can be saved, and that God will keep His promises to Israel.  The gifts and calling of God promised to Israel are for Israel and will be given to Israel despite how the Jews at that time were responding to the gospel.

Verse 29 does not mean that repentance is not necessary for individual salvation from sin.  To be saved one must recognize their sinfulness and call on Christ to save them as a sinner.  Paul is referring to the promises of God made to Israel that were unconditional.  Since God made unconditional promises to Israel, He will fulfill those promises despite the present heart condition of many of those people.

Application:

We should have a desire for all people, including Jewish people, to believe on Christ.  God has not cast away His people.  He loves them.  We also should trust in the promises of God.  He is a promise keeping, never changing God.

Response:

How are you doubting or trusting in the promises of God today?

Who can you share the salvation message with today?